Best Practice:

Purchase Resource and Offensive Aspect Caches early in the season or when starting a new character to get critical aspects and jewelry for your build.
As you progress, shift your focus toward Utility and Augment Caches to round out your gear and optimize your setup for endgame content.
2. Use Pale Marks to Restock Vendor Inventory
If the vendor’s current offerings don’t align with your build needs, you can spend 50 Pale Marks to restock the vendor's inventory after the free daily restock. This option allows you to take another chance at obtaining gear or aspects that suit your build.

When to Use Vendor Restocks:

Early Game: Early in the season, restocking can help you find essential gear and aspects to accelerate your build progression. Spend Pale Marks on restocks when you’re still hunting for specific gear or legendary aspects to Diablo 4 Items round out your build.
Late Game: As you approach the endgame, restocking is less useful unless you’re chasing specific high-end items or Diablo IV Items for sale rare legendary aspects.